Mr. Tsung Cho-Chang Memorial Electron Microscope Laboratory


With its high penetration and precision, Transmission Electron Microscope (TEM) is one of the most significant tools for scientific research. The College of Medicine established the Laboratory with donation from Mr. Tsung Cho-Chang Educational Foundation and the precision instrument fund from the College of Science and Engineering. The Laboratory provides services for teaching and research related to clinical medicine, basic medicine, life science, food technology, and material science.


Transmission electron microscopy
JEOL JEM-1400 Ultramicrotome
Leica EM UC7 Leica EM KMR3 Confocal Spectral Microscope
Leica TCS SP2
Transmission electron microscopy
Leica EM UC7
Leica EM KMR3 Confocal Spectral Microscope
Leica TCS SP2


Tissue fixer, ultra thin slicing, vital staining and intravital staining, specimen observation and photography


  • In principle, each user can reserve one unit (2 hours) at a time. When the lab is available, the user can reserve no more than two consecutive units. Users who arrive late for more than 30 minutes will lose their reservation. In cases when the experiments cannot be conducted, please cancel the reservation in advance.

  • Contact Staff: Mr. Yen-Shen Wu, Tel: +886-2-29052092.


  • Samples should be placed on brass screen (3mm in diameter)

  • Non-volatile

  • Non-ferromagnetic

  • Moisture-free

  • Non-Corrosive

Research result

  • Ramesh Kumar, B.Stephen Inbaraj, and B.H.Chen, (21 July 2010)Surface modification of superparamagnetic iron nanoparticles with calcium salt of poly(g-glutamicacid) as coating material. Materials Research Bulletin.

  • B Stephen Inbaraj, T H Kao, T Y Tsai, C P Chiu, R Kumar and B H Chen(14 January 2011) The synthesis and characterization of poly(γ -glutamic acid)-coated magnetite nanoparticles and their effects on antibacterial activity and cytotoxicity. Nanotechnology.

  • B.Stephen Inbaraj and B.H. Chen (June 24, 2011) Dye adsorption characteristics of magnetite nanoparticles coated with a biopolymer poly(r-glutamic acid). Bioresource Technology.

  • Yen-Yin Tsai, Yi-Huei Huang, Ya-Li Chao, Kuang-Yu Hu, Li-Te Chin, Shiu-Huey Chou, Ai-Ling Hour, Yeong-DerYao, Chi-Shun Tu, Yao-Jen Liang, Cheng-Yuh Tsai, Hao-YuWu, Shan-Wen Tan, and Han-Min Chen. (November 2, 2011) Identification of the Nanogold Particle-Induced Endoplasmic Reticulum Stress by Omic Techniques and Systems Biology Analysis. American Chemical Society NANO.

  • Baskaran Stephen Inbaraj and Bing-Huei Chen (9 August 2012) In vitro removal of toxic heavy metals by poly(γ-glutamic acid)-coated superparamagnetic nanoparticles. International Journal of Nanomedicine.

  • Kun-Long Hung, Su-Jane Wang, Ying-Chou Wang, Tsuey-Ru Chiang, Chia-Chuan Wang (29 October 2013) Upregulation of Presynaptic Proteins and Protein Kinases Associated with Enhanced Glutamate Release from Axonal Terminals (Synaptosomes) of the Medial Prefrontal Cortex in Rats with Neuropathic Pain. Pain.

  • C-H Lee, S-T Lin, J-J Liu, W-W Chang, J-L Hsieh and W-K Wang (23 January 2014) Salmonella induce autophagy in melanoma by the downregulation of AKT/mTOR pathway. Gene Therapy

  • Yi Jyun Chen, Baskaran Stephen Inbaraj, Yeong Shiau Pu and Bing Huei Chen(20 March 2014) Development of lycopene micelle and lycopene chylomicron and a comparison of bioavailability. Nanotechnology.

  • Fur-Jiang Leu, Chuen-Lin Huang, Yuh-Mou Sue, Shao-Chen Lee and Chia-Chen Wang(24 September 2014) Effects of tattoo ink’s absorption spectra and particle size on cosmetic tattoo treatment efficacy using Q-switched Nd:YAG laser. Lasers in Medical Science.

  • K Suresh Babu, M Anandkumar, TY Tsai, TH Kao, B Stephen Inbaraj and BH Chen (27 November 2014) Cytotoxicity and antibacterial activity of gold-supported cerium oxide nanoparticles. International Journal of Nanomedicine.

  • Yesudoss Christu Rajan, Baskaran Stepene Inbaraj and Bing Huei Chen (21st January 2015) Synthesis and characterization of poly (r-glutamic acid)-based alumina nanoparticles with their protein adsorption efficiency and cytotoxicity towards human prostate cancer cells. The Royal Society of Chemistry.

  • Rwei-Fen S Hunag, Yi-Jun Wei, Baskaran Stephen Inbaraj and Bing-Huei Chen (8 April 2015) Inhibition of Colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene. International Journal of Nanomedicine.

  • Hong-Bin Chang and Bing Huei Chen (6 August 2015) Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma Ionga Linnaeus. Internation Journal of Nanomedicine

  • Hong-Bin Chang and Bing Huei Chen (6 May 2016) Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3. Internation Journal of Nanomedicine

  • Nai-Hsing Ho, Baskaran Stephene Inbaraj and Bing Huei Chen (6 May 2016) Utilization of Microemulisions from Rhinacanthus nasutus(L.) Kura to Improve Carotenoid Bioavailability. Scinetific Reports

  • Tzu Yu Lin, Cheng Wei Lu, Su Jane Wang (13 May 2016)Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats. NeuroToxicology

  • Tsung-Hsuan Lai, Ching-Hu Chung, Bing-Huei Chen, Chi-Feng Hung, Baskaran Stephen Inbaraj, Ming-Chieh Ma, Han-Min Chen, Chih-Jen Tsou, Pi-Hui Wu, and Wen-Bin Wu (3 April 2016) Gold Nanoparticles Compromise TNF-a Induced Endothelial Cell Adhesion Molecule Expression Through NF-kB and Protein Degradation Pathways and Reduce Neointima Formation in a Rat Carotid Balloon Injury Model. Biomedical Nanotechnology

  • Hung-sheng Shang, Yi-No Wo, Chun-Hou Liao, Tzong-Shi Chiueh, Yuh-Feng Lin and Han-Sun Chiang (20 July 2016) Long-term administration of ketamine induces erectile dysfunction by decreasing neuronal nitric oxide synthase on cavernous nerve and increasing corporal smooth muscle cell apoptosis in rats. Oncotarget

  • W D Lee, Y J Liang and B H Chen (11 Nov 2016) Effects of tanshinone nanoemulsion and extract on inhibition of lung cancer cells A549. Nanotechnology

  • H J HSU, R F Huang, T H Kao, B S Inbaraj and B H Chen (7 march 2017) Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT-29 colon cancer cells. Nanotechnology

  • Ya-Yun Wang, Ying-Hung Lin, Yi-No Wu, Yen-Lin Cheng, Yung-Chih Lin, Chiao-Yin Cheng, Han-Sun Chiang (April 6,2017) Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice. PLOS of GENETICS

  • Ji-Fan Lin, Yi-Chia Lin, Te-Fu Tsai, Hung-En Chen, Kuang-Yu Chou and Thomas I-Sheng Hwang (16 May 2017) Cisplatin induces protective autophagy through activation of BECNI in human bladder cancer cells. Drug Design, Development and Therapy

  • Pei Shan Lu, Baskaran Stephen Inbaraj and Bing Huei Chen (18 May 2017) Determination of oral bioavailability of curcuminoid dispersions and nanoemulsions prepared from Curcuma longa Linnaeus.J Sci Food Argic

  • Chu-Ching Yang, Chi-Feng Hung and Bing-Huei Chen (5 Sep 2017) Preparation of coffee oil-algae oil-based nanoemulsions and the study of their inhibition effect on UVA-induced skin damage in mice and melanoma cell growth. International Journal of Nanomedicine

  • Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao and Han-Sun Chiang (16 October 2017) Spontaneous Regeneration of Nerve Fiber and Irreversibility of Corporal Smooth Muscle Fibrosis after Cavernous Nerve Crush Injury: Evidence From Serial Transmission Electron Microscopy and Intracavernous Pressure. Urology

  • Ya-Yun Wang, Han-Sun Chiang, Chian-Tin Cheng, Yi-No Wu, Yung-Chih Lin, Hsuan-Che Liu, Wei-Kung Tsai, Yen-Lin Chen and Ying-Hung Lin (29 Dec 2017) SLC9A3 Protein Is Critical for Acrosomal Formation in Postmeiotic Male Germ Cells. International Journal of Molecular Sciences